FETAL HYDANTOIN SYNDROME PDF

Disease definition. Fetal hydantoin syndrome is a drug-related embryofetopathy that can occur when an embryo/fetus is exposed to the anticonvulsant drug. A clinical diagnosis of fetal hydantoin syndrome secondary to in utero phenytoin exposure was considered. Investigations showed vitamin D. This page includes the following topics and synonyms: Fetal Hydantoin Syndrome.

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Association with EPHX1 has been suggested. Affected infants may also exhibit stiff, tapered fingers, underdeveloped fingers and toes, toes that resembled fingers digitalized toesand malformed, underdeveloped fingernails and toenails.

These images are a random sampling from a Bing search on the term “Fetal Hydantoin Syndrome. Determining the precise, underlying reasons why fetal hydantoin syndrome develops, requires further research to discover the specific genetic and environmental factors that play a role in the development of the disorder.

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Orphanet: Fetal hydantoin syndrome

Fetal antiepileptic drug exposure: Studies have indicated that fetal valproate syndrome is associated with greater risk of neurological and cognitive abnormalities than other anti-seizure medications. The epidemiology of epilepsy in Rochester, Minnesota, through Case Rep Anesthesiol ; Congenital malformation due to exogenous toxicity Q86 Sindrome fetale da idantoinaFetxl fetale da fenitoina.

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Oguni M, Osawa M. Phenytoin is often given with other anti-seizure drugs and other adjunct medications that may influence development of the disorder.

Its clinical manifestations include limb abnormalities, ocular defects, central nervous system anomalies, intrauterine growth restriction, and hand and phalangeal anomalies. Churchill Livingston Elsevier; Manifestations include dysmorphic craniofacial features, hypoplastic distal phalanges and nails, growth delay and delayed psychomotor development. Only syndroem written in English can be processed. Fetal hydantoin syndrome is a characteristic pattern of fetak and physical birth defects that results from maternal use of the anti-seizure anticonvulsant drug phenytoin Dilantin during pregnancy.

Fetal alcohol spectrum disorder. Related Topics in Pharmacology.

Biochemical and molecular teratology of fetal hydantoin syndrome. Methemoglobinemia is a rarely seen side effect.

Fetal hydantoin syndrome

From Wikipedia, the free encyclopedia. Anti-seizure medications, also known as antiepileptic or anticonvulsant medications are among the most common teratogens prescribed to women of childbearing age. Less commonly, microcephaly, ocular defects, oral clefts, umbilical and inguinal hernias, hypospadias and cardiac anomalies have also been reported. Causes Maternal use of anti-seizure medications such as phenytoin, which is often used to treat epileptic seizures, can result in multiple effects on the developing embryo and fetus, including fetal hydantoin syndrome.

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Another theory speculates that intermediate metabolites of phenytoin are responsible for its teratogenesis. The material is in no way intended to replace professional medical care featl a qualified specialist and should not be used as a basis for diagnosis or treatment.

Fetal hydantoin syndrome – Wikipedia

The concept of fetal antiepileptic syndromes in this regard is less useful than in the past and the broad consideration of the major and minor congenital malformations, various cognitive impairments, and behavioral abnormalities taken as a broader, collective concept is more appropriate.

The disorder may be characterized by abnormalities of the head and facial craniofacial area, resulting in a coarse facial appearance. NORD has a separate report on fetal valproate syndrome. Researchers believe the disease can be transmitted genetically as an autosomal dominant trait but most cases appear to be the result of a new mutation.

Growth deficiency may be mild to moderate in severity and can continue during the newborn period postnatal growth deficiency. Elsevier Saunders, Philadelphia, PA; A smaller population will have growth problems and developmental delayor intellectual disability.